In this tutorial, we learn about treating pimples overnight with toothpaste. This should only be used as a spot treatment overnight to dry the pimple out. Remember not to put this all over your face, or your face will become irritated and extremely dried out. Only put the toothpaste in the spot that your pimple is at. If you have very sensitive skin, this is not recommended. A good acne treatment and regiment is going to be the best method for not getting acne, but this is a great way to take care of acne if you have an event or party coming up and need to get rid of a zit.