Dr. Schultz explains how to get rid of spider veins. The best treatment for spider veins depends on where they are. 1. On your legs, the best treatment is injections. It takes one to several treatments after which you will then be advised to wear tight compression stockings for three days. 2. If the spider veins is on your face, the best treatment is lasers where they usually work the first time and is not painful. 3. See your dermatologist for a treatment to get rid of spider veins.