In this video Dr. Schultz will show you how to control extreme underarm sweating. If you suffer from extreme underarm sweating, despite regular use of antiperspirants, follow these steps: Make an appointment with your doctor so that they can give you a prescription for a topical antiperspirant called Drysol. This liquid is applied once a week, at bedtime, and is covered with cling wrap. After a few weeks you will see a significant reduction in the amount of underarm perspiration you experience. If the above mentioned treatment does not work, you may be required to undergo Botox treatments. You may need a total of 25 injections. This treatment usually lasts about 3-6 months. If excessive underarm sweating makes a difference in your quality of life, please see your dermatologist.